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Separation Modeling of Blood Cells using Dielectrophoretic Field Flow

by Ayat Nada, Mohamed Omar, Ahmed M. Sayed
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 181 - Number 33
Year of Publication: 2018
Authors: Ayat Nada, Mohamed Omar, Ahmed M. Sayed
10.5120/ijca2018918275

Ayat Nada, Mohamed Omar, Ahmed M. Sayed . Separation Modeling of Blood Cells using Dielectrophoretic Field Flow. International Journal of Computer Applications. 181, 33 ( Dec 2018), 36-41. DOI=10.5120/ijca2018918275

@article{ 10.5120/ijca2018918275,
author = { Ayat Nada, Mohamed Omar, Ahmed M. Sayed },
title = { Separation Modeling of Blood Cells using Dielectrophoretic Field Flow },
journal = { International Journal of Computer Applications },
issue_date = { Dec 2018 },
volume = { 181 },
number = { 33 },
month = { Dec },
year = { 2018 },
issn = { 0975-8887 },
pages = { 36-41 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume181/number33/30206-2018918275/ },
doi = { 10.5120/ijca2018918275 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-07T01:08:16.878998+05:30
%A Ayat Nada
%A Mohamed Omar
%A Ahmed M. Sayed
%T Separation Modeling of Blood Cells using Dielectrophoretic Field Flow
%J International Journal of Computer Applications
%@ 0975-8887
%V 181
%N 33
%P 36-41
%D 2018
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Improving the ability to separate particles and cells in a continuous flow pattern facilitates faster and incessant medical diagnosis. In this paper, a modified design is presented that is capable of separating platelet cells from other blood cells in a continuous flow. The modified device achieves the separation of platelets using Dielectrophoretics (DEP) mechanism. A two dimensional finite element model was exploited to test different design parameters, including the applied separation peak to peak voltage, frequency, and speed of the flow inlet. Simulations of the modified microfluidic device showed successful separation of the red blood cells from platelets and also from other mixed blood cells. The modeling and simulation results demonstrate that cell separation can be achieved with high purity levels of platelets of up to 99.8%. The device’s optimized technology makes it suitable for portable, bedside and point-of-care testing applications.

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Index Terms

Computer Science
Information Sciences

Keywords

Microfluidics Dielectrophoretics Finite Element Model Blood cell Separation Platelets(PLTs).

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