Call for Paper - November 2023 Edition
IJCA solicits original research papers for the November 2023 Edition. Last date of manuscript submission is October 20, 2023. Read More

A Study on Alzheimer’s Disease

International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Year of Publication: 2019
Akanksha Kaushik, Jyotsna Singh,

Akanksha Kaushik and Jyotsna Singh and. A Study on Alzheimer’s Disease. International Journal of Computer Applications 181(46):16-21, March 2019. BibTeX

	author = {Akanksha Kaushik and Jyotsna Singh and},
	title = {A Study on Alzheimer’s Disease},
	journal = {International Journal of Computer Applications},
	issue_date = {March 2019},
	volume = {181},
	number = {46},
	month = {Mar},
	year = {2019},
	issn = {0975-8887},
	pages = {16-21},
	numpages = {6},
	url = {},
	doi = {10.5120/ijca2019918589},
	publisher = {Foundation of Computer Science (FCS), NY, USA},
	address = {New York, USA}


Alzheimer’s disease is prolonged neurologically degraded disease which gets exaggerated with the course of time. While in its progression, Alzheimer’s disease gives rise to memory shortfall and cognitive fall off. It is a constituent of two pathological conditions i.e. Neurofibrillary tangles, which the clusters formed by hyperphosphorylation of microtubule related protein are called Tau, and Senile plaque which contains β-Amyloid, a neurotoxin, which causes impairment of synaptic plasticity and may also change the functionality of many ionic channels. These two deadly proteins are the sure signs of Alzheimer’s disease and attack the Hippocampus region thereby starts damaging the hippocampal pyramidal neurons in its early stage.

According to the survey on Alzheimer’s disease, it is the 6th main cause of deaths in US and in upcoming years, this will become the 3rd main cause of deaths. But, despite researches, therapies and awareness, the actual cause of Alzheimer’s disease is still a big question mark. “What is the actual cause of it”? “When and how it gets accumulated on a neuron”? “How a person can know if he is infected with this disease”? These are some of the questions that are yet to be answered.

In this paper, a detailed overview of the work done till now for the identification and treatment of Alzheimer’s disease is presented.


  1. T. Good, D. Smith, R. Murthy,” β-amyloid Peptide blocks the fast-inactivating K+ current in Rat Hippocampal Neurons” in Biophysical Journal, Jan 1996, Vol. 70, pp. 296-304.
  2. N. Webster, M. Ramsden, J. Boyle, H. Pearson, C. Peers,”Amyloid peptides mediate hypoxic increase of L-type Ca2+ channels in central neurons”, in Neurobiology of Aging, Mar 2006, Vol. 27, Issue 3, pp 439-445.
  3. M. Ahmadlou, H. Adeli, A. Adeli, ”New diagnostic EEG makers of Alzheimer’s disease using visibility graph ”, in Journal of Neural Transmission, Sep 2010, Volume 117, Issue 9, pp 1099–1109.
  4. R. Takahashi, E. Zarate, M. Lin, T. Milner, G. Gouras,”Co-occurrence of Alzheimer’s disease β-amyloid and tau pathologies at synapses”, in Neurobiology of Aging, July 2010, Vol. 31, Issue 7, pp 1145-1152.
  5. L. Colom, M. Castaneda, C. Banuelos, G. Puras, A. G. Hernandez, S. Hernandez, S. Mounsey, J. Benavidez, C. Lehker, ”Medial septal β-amyloid 1-40 injections alter septo-hippocampal anatomy and function ”, in Neurobiology of Aging, Jan 2010, Vol. 31, Issue 1, pp 46-57.
  6. T.M. Morse, N.T. Carnevale, P. G. Mutalik, M. Migliore, G. M. Shepherd, “Abnormal excitability of oblique dendrites implicated in early Alzheimer’s: a computational study” , in Frontiers in Neural Circuits, May 2010, Vol. 4, Article 16, pp. 1-11.
  7. X. Li, D. Coyle, L, Maguire, D. Watson, T. McGinnity, “Gray matter concentration and effective connectivity changes in Alzheimer’s disease: a longitudinal structural MRI study”, in Neuroradiology, Oct 2011, Vol. 53, Issue 10, pp 733–748.
  8. X. Zou, D. Coyle, K. Wong-Lin, L. Maguire, “Beta-amyloid induced changes in A-type K+ current can alter hippocampo-septal network dynamics”, in Journal of Computational Neuroscience, June 2012, Vol. 32, Issue 3, pp 465–477.
  9. P. Spies, J. Claassen, P. Peer, M. Blankenstein, C. Teunissen, P. Scheltens, W. Flier, M. Rikkert, M. Verbeek, “A prediction model to calculate probability of Alzheimer’s disease using cerebrospinal fluid biomarkers”, in The Journal of Alzheimer’s Association, May 2013, Vol. 9, Issue 3, pp 262-268.
  10. P. Maia, J. Kutz, “Compromised axonal functionality after neurodegeneration, concussion and/or traumatic brain injury”, in Journal of Computational Neuroscience, Oct 2014, Vol. 37, Issue 2, pp 317–332.
  11. K. Abuhassan, D. Coyle, A. Belatreche, L. Maguire, “Compensating for synaptic loss in Alzheimer’s disease”, in Journal of Computational Neuroscience, Feb 2014, Vol. 36, Issue 1, pp 19–37
  12. J. Grill, C. Cox, K. Harkins, J. Karlawish, “Reactions to learning a “not elevated” amyloid PET result in preclinical Alzheimer’s disease trial”, in Alzheimer’s Research and Therapy, Dec 2018, Vol. 10, Issue 125, pp 1-8.
  13. K. Dou, C. Tan, M.Tan, X. Cao, X. Hou, Q. Guo, L. Tan, V. Mok, J. Yu, “Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer’s disease: a network meta-analysis of 41 randomized controlled trials”, in Alzheimer’s Research and Therapy, Dec 2018, Vol. 10, Issue 126, pp 1-10.
  14. I. Baldeiras, I. Santana, M. Leitao, D. Vieira, D. Duro, B. Mroczko, J. Kornhuber, P. Lewczuk, “Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer’s disease”, in Alzheimer’s Research and Therapy, Jan 2019, Vol. 11, Issue 2, pp 1-11.
  15. J. Youm, J. Jeon, H. Kim, Y. Kim, K. Ko, H. Joung, H. Kim, “Transgenic tomatoes expressing human beta amyloid for use as a vaccine against Alzheimer’s disease”, in Biotechnology Letters, Oct 2008, Vol. 30, Issue 10, pp 1839–1845.
  16. P. Tiraboschi, L. Hansen, L, J, Thal, J. Corey-Bloom, “The importance of neuritic plaques and tangles to the development and evolution of AD”, in Neurology, June 2004, Vol. 62, no. 11, pp 1984-1989.
  17. J.A. Hardy, A.G. Higgins, “Alzheimer’s disease: the amyloid cascade hypothesis”, April 1992, Vol. 256, Issue 5054, pp. 184-185
  18. C. Holscher, S. Gengler, V.A. Gault, P.Harriott, H.A. Mallot, “Soluble beta-amyloid reversibly impairs hippocampal synaptic plasticity and spatial learning”, in European Journal of Pharmacology, April 2007, Vol. 561, Issue 1-3, pp. 85-90.
  19. H. Adeli, S. Ghosh-Dastidar, N. Dadmehr, “Alzheimer’s disease and models of computation: imaging, classification and neural models”, in Journal of Alzheimer’s Disease, June 2005, Vol. 7, no. 3, pp 187-199.


Alzheimer’s disease, neurofibrillary tangles, β-amyloid, tau protein