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In Silico Modeling of Human Toll like Receptor 1
| International Journal of Computer Applications |
| Foundation of Computer Science (FCS), NY, USA |
| Volume 61 - Number 8 |
| Year of Publication: 2013 |
| Authors: Jayasree Ganugapati, Rama Sashank Madhurapanthula, Krovvidi Siva Sai |
10.5120/9948-4592
|
Jayasree Ganugapati, Rama Sashank Madhurapanthula, Krovvidi Siva Sai . In Silico Modeling of Human Toll like Receptor 1. International Journal of Computer Applications. 61, 8 ( January 2013), 19-21. DOI=10.5120/9948-4592
Abstract
Toll-like receptors (TLRs) are membrane-spanning receptors that play a key role in the innate immune system. . They play an important role in providing innate immunity. TLR1 is one such protein that belongs to this family . It recognizes pathogen-associated molecular pattern and is specific for gram-positive bacteria. TLR1 dimerizes with TLR2 and identifies a mycobacterial lipoprotein . This interaction and recognition is considered to be a key step in the invasion of Mycobacterium based infections like tuberculosis. The protein structure for TLR1 has not yet been predicted, either theoretically or experimentally. This gave us scope for building a model structure for Human Toll like Receptor 1 using multiple templates and MODELLER 9v7 .
References
- L. S. Miller, "Toll-like receptors in skin," Advances in Dermatology, vol. 24, pp. 71–87, 2008. R.
- Medzhitov, "Toll-like receptors and innate immunity," Nature Reviews Immunology, vol. 1, no. 2, pp. 135–145, 2001.
- M. G. Netea, C. van der Graaf, J. W. M. Van der Meer, and B. J. Kullberg, "Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system," Journal of Leukocyte Biology, vol. 75, no. 5, pp. 749–755, 2004. J.
- Kim, M. -T. Ochoa, and M. -T. Ochoa, "Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses," Journal of Immunology, vol. 169, no. 3, pp. 1535–1541, 2002.
- Osamu Takeuchi et al Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins1 The Journal of Immunology, 2002, 169: 10-14.
- Aswin Hari et al The Role of Toll-like Receptors in the Pathogenesis and Treatment of Dermatological Disease Mediators of Inflammation Volume 2010 (2010),
- Richard I. Tapping et al Mycobacterial lipo arabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling Innate Immunity August 2003 vol. 9 no. 4 264-268
- SignlaP: http://www. cbs. dtu. dk/services/SignalP/
- HHSEARCH: http://toolkit. tuebingen. mpg. de/hhpred
- J. Garnier, J. -F. Gibrat, B. Robson GOR secondary structure prediction method version IV, , 1996 Methods in Enzymology,R. F. Doolittle Ed. , vol 266, 540-553,
- Thompson JD, Higgins DG, Gibson TJ CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994 Nov 11;22(22):4673-4680
- Sali, A. and Blundell, T. L 1993 Comparative protein modelling by satisfaction of spatial restraints. . . J. Mol. Biol. 234: 779-815.
- Paul de Bakker and Simon Lovell Structural validation by assessment of the Ramachandran Plot,
- Eisenberg D, Lüthy R, Bowie JU. VERIFY3D: assessment of protein models with three-dimensional profiles. Methods Enzymol. 1997;277:396-404.
- Laskowski RA, Hutchinson EG, Michie AD, Wallace AC, Jones ML, Thornton JM (December 1997). "PDBsum: a Web-based database of summaries and analyses of all PDB structures". Trends Biochem. Sci. 22 (12): 488–90.
- Guex, N. and Peitsch, M. C. (1997) SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling. Electrophoresis 18, 2714-2723
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