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Insilico Analysis of Protein-Ligand Docking of DHFR ( Dihydro Folate Reductase) and Quassinoids

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International Journal of Computer Applications
© 2013 by IJCA Journal
Volume 62 - Number 12
Year of Publication: 2013
Authors:
R. D. Shailima Vardhini
10.5120/10131-4919

Shailima R D Vardhini. Article: Insilico Analysis of Protein-Ligand Docking of DHFR ( Dihydro Folate Reductase) and Quassinoids. International Journal of Computer Applications 62(12):14-19, January 2013. Full text available. BibTeX

@article{key:article,
	author = {R. D. Shailima Vardhini},
	title = {Article: Insilico Analysis of Protein-Ligand Docking of DHFR ( Dihydro Folate Reductase) and Quassinoids},
	journal = {International Journal of Computer Applications},
	year = {2013},
	volume = {62},
	number = {12},
	pages = {14-19},
	month = {January},
	note = {Full text available}
}

Abstract

Quassinoids are the naturally available plant extracts which exhibit a wide range of biological activities , that include anti malarial, anti amoebic, anti tumor properties etc. The present experiment aims to exploit the antitumor properties of the quassinoids. 68 quassinoid analogues were designed and were docked with hDHFR (human dihydrofolate reductase) a potential cancer target. The docking results showed compound 33 to be the best ligand for DHFR.

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