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Volumetric Analysis of Regional Atrophy for the Differential Diagnosis of AD and FTD

by Tinu Varghese, Sheela Kumari R, P. S Mathuranath
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 62 - Number 20
Year of Publication: 2013
Authors: Tinu Varghese, Sheela Kumari R, P. S Mathuranath
10.5120/10215-5059

Tinu Varghese, Sheela Kumari R, P. S Mathuranath . Volumetric Analysis of Regional Atrophy for the Differential Diagnosis of AD and FTD. International Journal of Computer Applications. 62, 20 ( January 2013), 43-48. DOI=10.5120/10215-5059

@article{ 10.5120/10215-5059,
author = { Tinu Varghese, Sheela Kumari R, P. S Mathuranath },
title = { Volumetric Analysis of Regional Atrophy for the Differential Diagnosis of AD and FTD },
journal = { International Journal of Computer Applications },
issue_date = { January 2013 },
volume = { 62 },
number = { 20 },
month = { January },
year = { 2013 },
issn = { 0975-8887 },
pages = { 43-48 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume62/number20/10215-5059/ },
doi = { 10.5120/10215-5059 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T21:12:26.673904+05:30
%A Tinu Varghese
%A Sheela Kumari R
%A P. S Mathuranath
%T Volumetric Analysis of Regional Atrophy for the Differential Diagnosis of AD and FTD
%J International Journal of Computer Applications
%@ 0975-8887
%V 62
%N 20
%P 43-48
%D 2013
%I Foundation of Computer Science (FCS), NY, USA
Abstract

The aim of this study was to characterize the patterns of brain atrophy in Alzheimer's disease (AD) patients compared to FTD patients and healthy controls. This study assesses the brain gray matter (GM) and ROI abnormalities jointly to reveal differences in abnormal MRI patterns between the diseases. Hippocampal, amygdala and cingulate gyrus volume was measured by Magnetic Resonance Imaging in patients with AD (n=25), FTD (n=10) and in healthy control subjects (n= 20) The neuropsychological assessment was used to stratify subjects according to cognitive functions VBM was performed to characterize the voxel wise analysis of neuro anatomic changes that occur in AD and FTD based on 3D flash spoiled gradient sequence using standard parameters. Our findings suggest that the magnitude of amygdale atrophy is comparable to that of the hippocampus in the earliest clinical stages of AD and FTD. The severity of dementia increased associated with decreasing hippocampal volume. Measurement of hippocampal and amgdalar regions may facilitate differentiation between dementia subtypes. In this study, there was no evidence that cingulate regional atrophy is specifically associated with early-onset AD and FTD

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Index Terms

Computer Science
Information Sciences

Keywords

Alzheimer's disease Frontotemporal Dementia Voxel Based Morphometry Mini Mental State Examination

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