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Food Dyes are Inhibitors of Human Protein Tyrosine Phosphatases (PTP1B) Molecular Docking Studies

by Ismail Daoud, Mourad Mesmoudi, Said Ghalem
International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 86 - Number 6
Year of Publication: 2014
Authors: Ismail Daoud, Mourad Mesmoudi, Said Ghalem
10.5120/14988-1983

Ismail Daoud, Mourad Mesmoudi, Said Ghalem . Food Dyes are Inhibitors of Human Protein Tyrosine Phosphatases (PTP1B) Molecular Docking Studies. International Journal of Computer Applications. 86, 6 ( January 2014), 11-18. DOI=10.5120/14988-1983

@article{ 10.5120/14988-1983,
author = { Ismail Daoud, Mourad Mesmoudi, Said Ghalem },
title = { Food Dyes are Inhibitors of Human Protein Tyrosine Phosphatases (PTP1B) Molecular Docking Studies },
journal = { International Journal of Computer Applications },
issue_date = { January 2014 },
volume = { 86 },
number = { 6 },
month = { January },
year = { 2014 },
issn = { 0975-8887 },
pages = { 11-18 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume86/number6/14988-1983/ },
doi = { 10.5120/14988-1983 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T22:03:29.643726+05:30
%A Ismail Daoud
%A Mourad Mesmoudi
%A Said Ghalem
%T Food Dyes are Inhibitors of Human Protein Tyrosine Phosphatases (PTP1B) Molecular Docking Studies
%J International Journal of Computer Applications
%@ 0975-8887
%V 86
%N 6
%P 11-18
%D 2014
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Protein Tyrosine Phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are use full therapeutic agents for the treatment of diabetes. The aim of the current study is to identify PTP1B inhibitors by means of virtual screening with docking. Six food dyes molecules have been screened and based on energy MolDok scores and hydrogen bonding interactions. L5, L1 potential inhibitors were identified in cavity1 and 2 respectively.

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Index Terms

Computer Science
Information Sciences

Keywords

Diabetes PTP1B Food dyes Interactions Molecular Docking.