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Spiking Patterns of Hodgkin-Huxley Model in Alzheimer’s Disease: Effects Caused by Noise Current

by Shruti Gupta, Jyotsna Singh
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 94 - Number 11
Year of Publication: 2014
Authors: Shruti Gupta, Jyotsna Singh
10.5120/16390-5971

Shruti Gupta, Jyotsna Singh . Spiking Patterns of Hodgkin-Huxley Model in Alzheimer’s Disease: Effects Caused by Noise Current. International Journal of Computer Applications. 94, 11 ( May 2014), 33-38. DOI=10.5120/16390-5971

@article{ 10.5120/16390-5971,
author = { Shruti Gupta, Jyotsna Singh },
title = { Spiking Patterns of Hodgkin-Huxley Model in Alzheimer’s Disease: Effects Caused by Noise Current },
journal = { International Journal of Computer Applications },
issue_date = { May 2014 },
volume = { 94 },
number = { 11 },
month = { May },
year = { 2014 },
issn = { 0975-8887 },
pages = { 33-38 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume94/number11/16390-5971/ },
doi = { 10.5120/16390-5971 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T22:17:24.323803+05:30
%A Shruti Gupta
%A Jyotsna Singh
%T Spiking Patterns of Hodgkin-Huxley Model in Alzheimer’s Disease: Effects Caused by Noise Current
%J International Journal of Computer Applications
%@ 0975-8887
%V 94
%N 11
%P 33-38
%D 2014
%I Foundation of Computer Science (FCS), NY, USA
Abstract

In this paper we study the effect of noise on HH Model. Small-world, regular and random neural networks are the types of HH neuronal networks, which we study in spiking synchronization. External noise and Sub threshold stimulus are subjected to all the neurons. In neuronal membranes we study biophysically realistic HH neurons with intensity of intrinsic noise via voltage gated ion channels. There is an optimal strength of noise that is found in each of all the neuronal networks to induce maximal spiking synchronization. We further study that there is a range of synaptic conductance that is present in each of neuronal networks to induce the effect that an optimal strength maximizes the spiking synchronization of noise. Also, the effect diminishes if the synaptic conductance becomes small or large. The synaptic conductance decreases to maximize the effect as the connections between neurons increases.

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Index Terms

Computer Science
Information Sciences

Keywords

External Current noise current Strength Gaussian white noise Alzheimer's disease

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