Biological Significance of Nitrogen Containing Heterocyclic Compounds - A Mini Review
Rajni Gupta. Article: Biological Significance of Nitrogen Containing Heterocyclic Compounds - A Mini Review. IJCA Proceedings on International Conference on Advancements in Engineering and Technology ICAET 2015(8):18-23, August 2015. Full text available. BibTeX
@article{key:article,
author = {Rajni Gupta},
title = {Article: Biological Significance of Nitrogen Containing Heterocyclic Compounds - A Mini Review},
journal = {IJCA Proceedings on International Conference on Advancements in Engineering and Technology},
year = {2015},
volume = {ICAET 2015},
number = {8},
pages = {18-23},
month = {August},
note = {Full text available}
}
Abstract
Heterocyclic compounds are present in abundance in our surroundings. They owe their importance in the biological system due to uniqueness in their structural Skelton parts. They are naturally found in nucleic acid, vitamins, antibiotics, hormones etc. Nitrogen containing heterocyclic compounds are an important class of heterocyclic compounds that has paid significant contribution towards medicinal chemistry. The types of compounds depend upon number of nitrogen atoms and their position. e. g. Pyrimidine contains one nitrogen atom in ring skeleton. With two nitrogen atoms it is called diazine, pyrazine etc. However, the review tends to focus on the importance of Pyrimidine class of compounds and their role as antibacterial, antifungal, anti-malarial, anticancer and other agents. The review also includes some of the marketed drugs having Pyrimidine ring nucleus and their application.
References
- Gilchrist, Thomas Lonsdale; Gilchrist, T. L. Heterocyclic Chemistry, New York; Longman. (1997)
- Devprakash, AB Udaykumar, Journal of Pharmaceutical Research, 2011; 4(7):2436-2440
- T. Sasada, F. Kobayashi, N. Sakai, T. Konakahara, Organic Letters, 2009; 11:2161-2164
- Amir M, Javed S. A. and Kumar H; Indian J. Pharm. Sciences, 2007; 69(3):337-343
- O. Stanislaw, (2009), Jord. J. Chem, 4:1-15
- Jain M. K. , Sharnevas S. C. ; Organic Chem. ; 2008; 3:997-999
- 7. Desai K, Patel R,Chickhalia K J. Ind. Chem. ,2006;45:773-778
- Amr EA, Nermien MS, Abdulla MM. Monatsh Chem. , 2007; 138:699-707
- Wagner E, Al-Kadsi K, Zimecki M, Sawka-Dobrowolska W. Eur J Med Chem. ,2008;43:2498-2504. Some of these marketed drugs are listed above. The biological significance of pyrimidine reflects its versatility and it offers the medicinal chemist a continued interest in planning and developing new drug to ensure heterocyclic chemistry, an area of great interest.
- Gorlitzer K, Herbig S, Walter Rd. Pharmazie, 1997; 52:670-672
- Jean-Damien C, David B, Ronald K, Julian G, Pan L, Robert D. Vertex Pharmaceuticals Incorporated, USA, PCT Int. Appl. 2002; 22:608
- Fujiwara N, Nakajima T, Ueda Y, Fujita HK, Awakami H. Bioorg Med. Chem. Lett. ,2007;17:1736-1740
- . Kurono M, Hayashi M, Miura K, Isogawa Y, Sawai K, Kokai Tokkyo Koho JP 1987;62:267-272, Chem. Abstr, 1988;109:37832
- Polak A. and Scholer HJ; Chemotherapy, 1975; 21:113
- A. Sacchi, S. Laneri, F. Arena, E. Luraschi and F. Rossi, Eur. J. Med. Chem. ,32,667(1997)
- H. B. Cottom, D. B. Wasson, H. C. Shih, G. D Pasquale and D. A. Carson, J. Med. Chem. ,36,3424(1993)
- Komis I and Wick A; Helv. Chim. Acta, 1997; 60:3025
- . P. Molina; E. Aller, A. Lorengo, P. L. Cremadis, I. Rioja and M. J. Alcaraz, J. Med. Chem. ,44,1011(2011)
- O. Bruno, C. Brullo; A. Ranise, S. Schenone, S. Bondavalls, M. Tognolini and M. Impicciatore, Bioorg. Med. Chem. Lett. , 11, 1379(2001)
- Gogia, Prabin Chandera (Reg Research Lab. ) Jorhat 785006. Indian Heterocycles, 1991; 32(10)
- Sondhi SM, Verma RP; Indian Drugs, 1999; 36(1):50
- Rathod IS, Pillai AS and Shirsath VS; Indian J. Heterocyclic Chem. ; 2000; 10; 93.
- M. S. El-Gaby, S. G. Abdel-Hamide and M. M. Gharab, Acta. Pharm. , 49(3), 149(1999); Chem. Abstr, 132, 93278d (2000).