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Reseach Article

Insilico Docking Analysis of Nitrogen Containing Bisphosphonate with Human Fernasyl Pyrophosphate Synthase

Published on February 2013 by Jyotsna Choubey, Ashish Patel, M. K. Verma
National Seminar on Application of Artificial Intelligence in Life Sciences 2013
Foundation of Computer Science USA
NSAAILS - Number 1
February 2013
Authors: Jyotsna Choubey, Ashish Patel, M. K. Verma
910ae2c3-13c2-440a-aa5f-c360f8328aba

Jyotsna Choubey, Ashish Patel, M. K. Verma . Insilico Docking Analysis of Nitrogen Containing Bisphosphonate with Human Fernasyl Pyrophosphate Synthase. National Seminar on Application of Artificial Intelligence in Life Sciences 2013. NSAAILS, 1 (February 2013), 66-72.

@article{
author = { Jyotsna Choubey, Ashish Patel, M. K. Verma },
title = { Insilico Docking Analysis of Nitrogen Containing Bisphosphonate with Human Fernasyl Pyrophosphate Synthase },
journal = { National Seminar on Application of Artificial Intelligence in Life Sciences 2013 },
issue_date = { February 2013 },
volume = { NSAAILS },
number = { 1 },
month = { February },
year = { 2013 },
issn = 0975-8887,
pages = { 66-72 },
numpages = 7,
url = { /proceedings/nsaails/number1/10773-1009/ },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Proceeding Article
%1 National Seminar on Application of Artificial Intelligence in Life Sciences 2013
%A Jyotsna Choubey
%A Ashish Patel
%A M. K. Verma
%T Insilico Docking Analysis of Nitrogen Containing Bisphosphonate with Human Fernasyl Pyrophosphate Synthase
%J National Seminar on Application of Artificial Intelligence in Life Sciences 2013
%@ 0975-8887
%V NSAAILS
%N 1
%P 66-72
%D 2013
%I International Journal of Computer Applications
Abstract

Bisphosphonates are currently the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia. These compounds have high affinity for calcium ions and therefore target bone mineral, where they are internalized by bone-resorbing osteoclasts and inhibit osteoclast function. Nitrogen-containing bisphosphonates (N-BPs) are currently used as clinical inhibitors of bone-resorption diseases. It target osteoclast farnesyl pyrophosphate synthase (FPPS) and inhibit protein prenylation. FPPS, a key branchpoint of the mevalonate pathway, catalyzes the successive condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate and geranyl pyrophosphate. In this study the docking accuracy and scoring reliability for the docking of nitrogen containing bisphosphonate with human FPPS using Auto Dock 4.0 has been presented the most potent drug for the treatment of osteoporosis.

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Index Terms

Computer Science
Information Sciences

Keywords

fernasyl pyrophosphate synthase osteoclast docking bisphosphonates hypercalcemia