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Computer-Aided Drug Design for NS5 Protein of Zika Virus

by Jayasree Ganugapati, Vaishnavi Tammara, Mary Nikitha Zakkam, M. Shaistha Afreen
journal cover thumbnail

International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 179 - Number 8
Year of Publication: 2017
Authors: Jayasree Ganugapati, Vaishnavi Tammara, Mary Nikitha Zakkam, M. Shaistha Afreen
10.5120/ijca2017916019

Jayasree Ganugapati, Vaishnavi Tammara, Mary Nikitha Zakkam, M. Shaistha Afreen . Computer-Aided Drug Design for NS5 Protein of Zika Virus. International Journal of Computer Applications. 179, 8 ( Dec 2017), 19-23. DOI=10.5120/ijca2017916019

@article{ 10.5120/ijca2017916019,
author = { Jayasree Ganugapati, Vaishnavi Tammara, Mary Nikitha Zakkam, M. Shaistha Afreen },
title = { Computer-Aided Drug Design for NS5 Protein of Zika Virus },
journal = { International Journal of Computer Applications },
issue_date = { Dec 2017 },
volume = { 179 },
number = { 8 },
month = { Dec },
year = { 2017 },
issn = { 0975-8887 },
pages = { 19-23 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume179/number8/28757-2017916019/ },
doi = { 10.5120/ijca2017916019 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-07T00:54:48.864815+05:30
%A Jayasree Ganugapati
%A Vaishnavi Tammara
%A Mary Nikitha Zakkam
%A M. Shaistha Afreen
%T Computer-Aided Drug Design for NS5 Protein of Zika Virus
%J International Journal of Computer Applications
%@ 0975-8887
%V 179
%N 8
%P 19-23
%D 2017
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Zika virus is an arbovirus that spreads through mosquito bites, sexual transmission, pregnancy and blood transfusions. The infection can be severe leading to birth defects, Guillen- Barre syndrome or it may be mild showing no symptom at all. The present study, aims at using Computer aided drug design to speed up the process of drug discovery by rapid optimization of lead compounds through virtual screening and predicting bioactivity. Docking studies were conducted to screen compounds against NS5 protein of Zika virus. The pharmacokinetic properties of the lead compounds were analysed using online tools.

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Index Terms

Computer Science
Information Sciences

Keywords

Zika virus NS5protein flavonoids

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