The week's pick
Random Articles
Reseach Article
Docking Studies on Identified Constituents of Helicteres isora as Antidiabetic Agents
| International Journal of Computer Applications |
| Foundation of Computer Science (FCS), NY, USA |
| Volume 45 - Number 20 |
| Year of Publication: 2012 |
| Authors: N.a Aleykutty, Akhila.s |
10.5120/7031-9437
|
N.a Aleykutty, Akhila.s . Docking Studies on Identified Constituents of Helicteres isora as Antidiabetic Agents. International Journal of Computer Applications. 45, 20 ( May 2012), 8-13. DOI=10.5120/7031-9437
Abstract
Diabetes mellitus is one of the major disease currently affecting an estimated 143 million people worldwide and the number is growing rapidly. Now a day, as there is a renewed interest in the traditionally used herbal drugs, the present study was aimed to screen the identified constituents of Helicteres isora for determining the potent constituent with antidiabetic activity using insilico approach. Docking studies of the constituents were carried out using autodock 4. 0 and the receptors used were aldose reductase and insulin receptor protein. Analysis of the results showed that, with both the receptors, yohimbine had the best binding energy and so most potent antidiabetic constituent among the identified constituents of Helicteres isora.
References
- Satyavati, G. V; Neeraj, T; Madhu, S. Indigenous Plant drugs for diabetes mellitus. Diabetes bulletea. 1989, 164Q- 190Q.
- Naggar, E. M; Necas, T; Strnadova, V. et al. Antidiabetic effect of Cleome droserifolia aerial parts: lipid peroxidation – induced oxidative stress in diabetic rats. Acta Vet Brno. 2005, 74, 347-352.
- Oubre, A. Y; Carlson, T. J; King, S. R; Reaven, G. M. From plant to patient: an ethanobotanical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia. 1997, 40, 614-617.
- Tripoathi, Y. B. A scientific approach for herbal drug research. In: Rakesh, K. S; Rajesh, A. (Ed). Herbal drugs: a twenty first century prospective. 2006,175-177.
- Sashikanth, C; Ajay, B. P; Gulla, V. Et al. Screning and docking studies of 266 compounds from 7 plant sources as antihypertensive agents. J Comput Sci Syst Biol. 2010, 3(1), 16-20.
- CSIR. The Wealth of India: Raw materials. 1988,
- Filomena, C; Giancarlo, A. S; Rosa, T; Monica, R. L; Farnesco, M. Invitro activities of Citrus medica diamante relevant to treatment of diabetes and alzheimer's disease. Phytother res. 2007, 21, 427-433.
- Shuichi, M. Molecular modelling and structure based drug discovery studies of aldose reductase inhibitors. Chem Bio Informatics J. 2002, 2(3), 74-85.
- Jayasree, G; Sirisha, M; Sahithi, A. Docking Studies of green tea flavonoids as insulin mimetics. International journal of computer applications. 2011, 30(4), 48-52.
- PDB Database:http://www. rcsb. org/ pdb/home/home. do
- Guex, N; Peitsch, M. C. Swiss Model and the swiss pdb viewer: An environment for comparative protein modelling. Electrophoresis,18, 2714-2723.
- Thompson; Mark, A. "Argus lab 4. 01" www. arguslab. com plknaria software LLc, Seattle, WA.
- Sundararajan, S; BAlajee, M; Dhanarajan, M. S. comparative docking analysis of neuraminidase with various inhibitors. 2010, 2(3), 83-5.
- Morris, G. M; Goodsell, D. S. et al. Automated docking using a Lamarckian Genetic and empirical binding free energy function. J Computational Chemistry,19, 1639-1662.
- Jayasree, G; Aashish,B; Sarfaraz,L. Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus. 2012, 8(5), 216-220.
Index Terms
Keywords