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Reseach Article

Modeling the Interactions between the BDNF Peptides and TrkB Receptor

by Dharmaiah Devarapalli, Allam Appa Rao, G R Sridhar
International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 55 - Number 9
Year of Publication: 2012
Authors: Dharmaiah Devarapalli, Allam Appa Rao, G R Sridhar
10.5120/8786-2759

Dharmaiah Devarapalli, Allam Appa Rao, G R Sridhar . Modeling the Interactions between the BDNF Peptides and TrkB Receptor. International Journal of Computer Applications. 55, 9 ( October 2012), 42-45. DOI=10.5120/8786-2759

@article{ 10.5120/8786-2759,
author = { Dharmaiah Devarapalli, Allam Appa Rao, G R Sridhar },
title = { Modeling the Interactions between the BDNF Peptides and TrkB Receptor },
journal = { International Journal of Computer Applications },
issue_date = { October 2012 },
volume = { 55 },
number = { 9 },
month = { October },
year = { 2012 },
issn = { 0975-8887 },
pages = { 42-45 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume55/number9/8786-2759/ },
doi = { 10.5120/8786-2759 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T20:56:50.429770+05:30
%A Dharmaiah Devarapalli
%A Allam Appa Rao
%A G R Sridhar
%T Modeling the Interactions between the BDNF Peptides and TrkB Receptor
%J International Journal of Computer Applications
%@ 0975-8887
%V 55
%N 9
%P 42-45
%D 2012
%I Foundation of Computer Science (FCS), NY, USA
Abstract

The BDNFTrkB signaling system which plays a major role in the regulation of neuronal activity. This neuronal regulation influences the potential role of this system in the therapeutic efficacy of many neurological and psychiatric disorders. Despite these roles decreased levels of BDNF are associated with diabetes and obesity which can be regulated by increasing the insulin sensitivity and glucose tolerance. BDNF mediated signaling through phosphoinositide 3-kinase (PI3K) pathway plays a key role in insulin sensitivity. These beneficial effects of BDNF as antidiabetic agents can be enhanced by the activating BDNFTrkB signaling. These multiple functionality of BDNFTrkB complex relies on the protein-protein interactions where those interactions are important in designing pharmacological targets. This apporach focus the use of BDNF peptides in place of BDNF protein in binding to the TrkB receptor. Protein–peptide docking studies were performed to know the interactions of the TrkB and BDNF peptides. Docking studies were done using ZDOCK pro (Accerlys Discovery studio). The interacting amino acids residues identified at the binding site were THR 306, LYS 308, CYS 5 ASP 370.

References
  1. Cochran, A. G. (2000) Chem. Biol. 7, R85–R94. .
  2. Toogood, P. L. (2002) J. Med. Chem. 45, 1543–1558.
  3. Berg, T. (2003) Angew. Chem. Int. Ed. 42, 2462–2481.
  4. Eisenberg D, Marcotte E M, Xenarios I and Yeates T O 2000 Protein function in the post-genomic era; Nature (London) 405 823–826.
  5. Cusick ME, Klitgord N, Vidal M, Hill DE. Interactome: gateway into systems biology. Hum. Mol. Genet. 14(2), R171–R181 (2005).
  6. Vidal M. A unifying view of 21st century systems biology. FEBS Lett. 583(24), 3891–3894 (2009).
  7. White AW, Westwell AD, Brahemi G (2008) Protein-protein interactions as targets for small-molecule therapeutics in cancer. Expert Reviews in Molecular Medicine 10: 1-14.
  8. Fry DC, Vassilev LT (2005) Targeting protein-protein interactions for cancer therapy. Journal of Molecular Medicine 83: 955-963.
  9. Arkin M (2005) Protein-protein interactions and cancer: small molecules going in for the kill. Current Opinion in Chemical Biology 9: 317-324.
  10. Benyamini, Future M 1002 ed. Chem. (2010) 2(6).
  11. Pettit, F. K. ; Bowie, J. U. J. Mol. Biol. , 1999, 285, 1377.
  12. Lewin GR, Barde WA. Physiology of the neurotrophins. Annu Rev Neurosci 1996;19:289 - 317.
  13. Mattson MP, Maudsley S, Martin B (2004) A neural signaling triumvirate that influences ageing and age-related disease: Insulin/IGF-1, BDNF and serotonin. Ageing Res Rev 3: 445–464.
  14. Reichardt LF (2006) Neurotrophin-regulated signaling pathways. Philos Trans R Soc Lond B Biol Sci 361:1545–1564.
  15. Barde YA (1994) Neurotrophins: A family of proteins supporting the survival of neurons. Prog Clin Biol Res 390: 45–56.
  16. Pedersen BK, Pedersen M, Krabbe KS, et al. Role of exerciseinduced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals. Exp Physiol 2009;94:1153e1160.
  17. Nakagawa T, Tsuchida A, Itakura Y, et al. Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 2000;49:436- 44.
  18. Tsuchida A, Nonomura T, Nakagawa T, et al. Brain-derived neurotrophic factor ameliorates lipid metabolism in diabetic mice. Diabetes Obes Metab 2002;4:262 - 9.
  19. Tsuchida A, Nonomura T, Kishino M, et al. Acute effects of brain derived neurotrophic factor on energy expenditure in obese diabetic mice. Int J Obes Relat Metab Disord 2001;25:1286- 93.
  20. Ono M, Ichihara J, Nonomura T, Itakura Y, Taiji M, Nakayama C and Noguchi H (1997) Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem Biophys Res Commun 238, 633-637.
Index Terms

Computer Science
Information Sciences

Keywords

BDNFTrkB signaling system Protein–protein interactions Protein–peptide interaction Diabetes mellitus