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Synthesis, Characterization and Substituent Effect on Biological Properties of Schiff Bases Derived from Anthranilic Acid

Published on November 2014 by Avinash Joshi, Oma Ram, Naveen Kumar Mawar, Vimla Chowdhary
journal_cover_thumbnail

National Conference on Innovations and Recent Trends in Engineering and Technology
Foundation of Computer Science USA
NCIRET - Number 1
November 2014
Authors: Avinash Joshi, Oma Ram, Naveen Kumar Mawar, Vimla Chowdhary
7d2d9831-bbd2-48e8-9673-074a459f3e92

Avinash Joshi, Oma Ram, Naveen Kumar Mawar, Vimla Chowdhary . Synthesis, Characterization and Substituent Effect on Biological Properties of Schiff Bases Derived from Anthranilic Acid. National Conference on Innovations and Recent Trends in Engineering and Technology. NCIRET, 1 (November 2014), 14-17.

@article{
author = { Avinash Joshi, Oma Ram, Naveen Kumar Mawar, Vimla Chowdhary },
title = { Synthesis, Characterization and Substituent Effect on Biological Properties of Schiff Bases Derived from Anthranilic Acid },
journal = { National Conference on Innovations and Recent Trends in Engineering and Technology },
issue_date = { November 2014 },
volume = { NCIRET },
number = { 1 },
month = { November },
year = { 2014 },
issn = 0975-8887,
pages = { 14-17 },
numpages = 4,
url = { /proceedings/nciret/number1/18621-1906/ },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Proceeding Article
%1 National Conference on Innovations and Recent Trends in Engineering and Technology
%A Avinash Joshi
%A Oma Ram
%A Naveen Kumar Mawar
%A Vimla Chowdhary
%T Synthesis, Characterization and Substituent Effect on Biological Properties of Schiff Bases Derived from Anthranilic Acid
%J National Conference on Innovations and Recent Trends in Engineering and Technology
%@ 0975-8887
%V NCIRET
%N 1
%P 14-17
%D 2014
%I International Journal of Computer Applications
Abstract

The effect of substituents on biological activity of Schiff bases was investigated using Schiff bases derived from the condensation of oxindol with, 4-methyl anthranilic acid, 4-methoxy anthranilic acid, 4-nitro anthranilic acid, 4-chloro anthranilic acid and 4-hydroxy anthranilic acid. The synthesized compounds are characterized by elemental analysis, IR and 1HNMR. The compounds were screened against important bacteria namely Staphylococcus aureus, Escherichia coli and Bacillus Subtilis bacterial strains and for in vitro antifungal activity against Candida albicans and Aspergillus niger using the agar cup plate method and radial growth method respectively and results show that 4-chloro anthranilic acid Schiff base exhibited highest activity.

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Index Terms

Computer Science
Information Sciences

Keywords

Oxindol Schiff Base Substituent Effect Biological Activity 1hnmr