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Assessing the accuracy of computational tools for the prediction of amyloid fibril forming motifs: an overview

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Computational Science - New Dimensions & Perspectives
© 2011 by IJCA Journal
Number 4 - Article 5
Year of Publication: 2011
Authors:
Smitha Sunil Kumaran Nair
N. V. Subba Reddy
Hareesha K. S

Smitha Sunil Kumaran Nair, Subba N V Reddy and Hareesha K S. Assessing the Accuracy of Computational tools for the Prediction of Amyloid Fibril forming Motifs: an overview. IJCA Special Issue on Computational Science - New Dimensions & Perspectives (4):155–157, 2011. Full text available. BibTeX

@article{key:article,
	author = {Smitha Sunil Kumaran Nair and N. V. Subba Reddy and Hareesha K. S},
	title = {Assessing the Accuracy of Computational tools for the Prediction of Amyloid Fibril forming Motifs: an overview},
	journal = {IJCA Special Issue on Computational Science - New Dimensions & Perspectives},
	year = {2011},
	number = {4},
	pages = {155--157},
	note = {Full text available}
}

Abstract

Identifying amyloidogenic regions in protein sequences is useful in understanding the underlying cause of several human diseases and finding potential therapeutic targets. Given the laborious nature of experimental validation of segments most prone to form fibrils, it was essential that computational approaches be developed that could produce reliable, affordable and testable in silico predictions. In this paper, we present and assess some of the recently developed computational tools for predicting amyloid fibril forming motifs that remain as one of the key means used to decipher the role of such regions in disease diagnosis, prognosis and drug discovery.

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